ERAD linked to obesity

Liberal trade laws linked to obesity.

Birth weight linked to diabetes and obesity

“It’s fascinating to see that the genes that play a role in birth weight also play a role in different diseases. By studying these genes, we can also see which proteins are involved and shine a spotlight on the mechanisms that can lead to these diseases,” says co-author Hans Bisgaard, professor of pediatrics and the head of the Copenhagen Studies on Asthma in Childhood research center (COPSAC) ...

Adipocytokines and obesity-linked disorders.

Obesity is closely associated with an increased risk for metabolic and cardiovascular diseases. Adipose tissue produces a number of secretory bioactive substances, also known as adipocytokines or adipokines, which directly affect adjacent or distant organs. Most adipocytokines are pro-inflammatory, thereby promoting the obesity-linked disorders. In contrast, there are a small number of adipocyt...

Ubiquitylation in ERAD: Reversing to Go Forward?

Proteins are co-translationally inserted into the endoplasmic reticulum (ER) where they undergo maturation. Homeostasis in the ER requires a highly sensitive and selective means of quality control. This occurs through ER-associated degradation (ERAD).This complex ubiquitin-proteasome–mediated process involves ubiquitin conjugating enzymes (E2) and ubiquitin ligases (E3),lumenal and cytosolic ch...

Single Gene Linked to Severe Obesity in Humans

A recent study published in Nature Genetics, describes a genetic link to obesity in humans discovered by studying obese children in Pakistan. One of the reasons that the genetics were uncovered in this region is because of the frequency of consanguinous (within the family) relationships. The genes that were identified are recessive mutations and exhibit a trait when two copies of the mutation a...